Cale Street, PhD, MBA – Profile
Cale Street completed both a Bachelor of Science in Pharmacology and a PhD in Experimental Surgery at the University of Alberta, and also holds an MBA from the University of Washington Business School. His research career spans several different fields in both academic and industrial settings. Early in his career, Dr. Street was a member of the University of Alberta team that developed and performed the first successful islet cell transplant for the treatment of type 1 juvenile diabetes; now known worldwide as the "Edmonton Protocol". He also performed research relating to tissue response to implanted biomaterials and biological response of the skin to mechanical stress in the Bioengineering Department at the University of Washington. More recently, his research has focused on non-antibiotic antibacterial technologies and their application to infection control in healthcare settings. Dr. Street has presented his work at major national and international scientific conferences, and has published multiple original research and review articles in peer-reviewed scientific journals (for a complete reference list click here). He currently holds the position of Vice President of Research with Ondine Biomedical Inc (TSX:OBP). He also runs the company's program relating to development of novel approaches to address hospital acquired infections (HAI's), including those caused by the superbug MRSA.
- Street CN, Pedigo L, Loebel NG (2010) Energy dose parameters affect antimicrobial photodynamic therapy-mediated eradication of periopathogenic biofilm and planktonic cultures. Photomedicine and Laser Surgery (in press)
- Street CN, Gibbs A (2010) Eradication of the corrosion-causing bacterial strains Desulfovibrio vulgaris and Desulfovibrio desulfuricans in planktonic and biofilm form using photodisinfection. Corrosion Science 52(4):1447-1452
- Braham P, Herron C, Street CN, Darveau RP (2009) Antimicrobial photodynamic therapy may promote periodontal healing through multiple mechanisms. Journal of Periodontology 80(11):1790-1798
- Zolfaghari PS, Packer S, Singer M, Nair SP, Bennett J, Street C, Wilson M (2009) In vivo killing of Staphylococcus aureus using a light activated antimicrobial agent. BMC Microbiology 9:27
- Street CN, Pedigo L, Gibbs A, Loebel NG (2009) Antimicrobial photodynamic therapy for the decolonization of methicillin-resistant Staphylococcus aureus from the anterior nares. Proceedings of the SPIE 7380:73803-B1
- Pedigo L, Gibbs A, Scott R, Street CN (2009) Absence of bacterial resistance following repeat exposure to photodynamic therapy. Proceedings of the SPIE 7380:73803H-73803H7.
- Street CN, Gibbs A, Pedigo L, Andersen D, Loebel NG (2008) In vitro photodynamic eradication of Pseudomonas aeruginosa in planktonic and biofilm culture. Photochemistry and Photobiology 85(1):137-143
- Gil-Tomas J, Tubby S, Parkin IP, Narband N, Dekker L, Nair SP, Wilson M, Street C (2007) Lethal photosensitization of Staphylococcus aureus using a toluidine blue O-tiopronin-gold nanoparticle conjugate. Journal of Materials Chemistry 17:3739-3746
- Street CN, Lakey JRT, Shapiro AMJ, Imes S, Rajotte RV, Ryan EA, Lyon JG, Kin T, Avila J, Tsujimura T, Korbutt GS (2004) Islet graft assessment in the Edmonton Protocol: Implications for predicting long-term clinical outcome. Diabetes 53:3107-3114
- Street CN, Lakey JRT, Rajotte RV, Shapiro AMJ, Kieffer TJ, Lyon JG, Kin T, Korbutt GS (2004) Enriched human pancreatic ductal cultures obtained from selective death of acinar cells express Pancreatic and Duodenal Homeobox Gene-1 age dependently. The Review of Diabetic Studies 1:66-79
- Street CN, Sipione S, Helms L, Binette T, Rajotte RV, Bleackley RC, Korbutt GS (2004) Stem cell based approaches to solving the problem of tissue supply for islet transplantation in type 1 diabetes. International Journal of Biochemistry and Cell Biology 36:667-683
- Street CN, Lakey JRT, Seeberger K, Helms L, Rajotte RV, Shapiro AMJ, Korbutt GS (2004) Heterogenous expression of nestin in human pancreatic tissue precludes its use as an islet precursor marker. The Journal of Endocrinology 180(2):213-225
- Street CN, Korbutt GS (2003) Stem cells as a source of islets for transplantation in type 1 diabetes: Scientific and ethical considerations. Canadian Journal of Diabetes 27(3):262-270
- Street CN, Rajotte RV, Korbutt GS (2003) Stem cells: A promising source of pancreatic islets for transplantation in type 1 diabetes. Current Topics in Developmental Biology 58:111-136